Epigenetics.doc

1 Page
117 Views
Unlock Document

School
University of Toronto Scarborough
Department
Anthropology
Course
ANTC62H3
Professor
Larry Sawchuk
Semester
Winter

Description
EpigeneticsThe term epigenetics defines all meiotically and mitotically heritable changes in gene expression that are not coded in the DNA sequence itself Three systems including DNA methylation RNAassociated silencing and histone modification are used to initiate and sustain epigenetic silencing Unravelling the relationships between these component has led to surprising and rapidly evolving new concepts showing how they interact and stabilize each other Fig 1 Disruption of one or other of these interacting systems can lead to inappropriate expression or silencing of genes resulting in epigenetic diseasesMulticellular organisms require mutually reinforcing mechanisms permitting heritable patterns of gene silencing Mutations in genes that affect global epigenetic profiles can give rise to human diseases which can be inherited or somatically acquired Table 1 Interestingly many of these epigenetic abnormalities result in chromosomal alterations and learning disabilitiesSeveral inherited syndromes are due to faulty genomic imprintingdefined as parentspecific monoallelic expression of a genesuch as Angelmans syndrome PraderWilli syndrome and Beckwith Wiedemann syndrome BWS In these conditions an abn
More Less

Related notes for ANTC62H3

Log In


OR

Don't have an account?

Join OneClass

Access over 10 million pages of study
documents for 1.3 million courses.

Sign up

Join to view


OR

By registering, I agree to the Terms and Privacy Policies
Already have an account?
Just a few more details

So we can recommend you notes for your school.

Reset Password

Please enter below the email address you registered with and we will send you a link to reset your password.

Add your courses

Get notes from the top students in your class.

Submit