Textbook Notes (362,734)
Canada (158,032)
Neuroscience (289)
NROC61H3 (42)
Chapter 15

Chapter 15 - Exam Notes

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University of Toronto Scarborough
Le Boutillier

Chapter 15Diffuse Modulatroy Systems of the Brain Drugs and the Diffuse Modulatory Systems Psychoactive drugs compounds with mindaltering effects all act on the CNS and most do so by interfering with chemical synaptic transmission Many abused drugs act on the noradrenergic dopaminergic and serotonergic sysytems Hallucinogens Hallucinogenic compounds are contained in a number of plants consumed as part of religious ritual eg Psilocybe mushroom by the Maya and peyote cactus by the AztecAlbert Hofmann chemically synthesized a new compound lysergic acid diethlamide LSD which is an extremely potent drug25microgramsFullblown hallucinogenic effect 25 000 larger than aspirinSymptoms Dreamlike state with heightened awareness of sensory stimuli often with a mixing of perceptions such that sounds can evoke images images evoke smells etcChemical structure is similar to 5HT and acts on the serotonergic system LSD is a potent agonist at the 5HT receptors on the presynaptic terminals of neurons in the raphe nucleiActivation at t
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