PSYB32H3 Chapter 2: Current Paradigms and Integrative Approaches
Document Summary
1) the family method can be done b/c the avg # of genes shared by 2 blood relatives is known first degree relatives (cid:224) share 50% of genetic makeup second degree relatives (cid:224) share 25% of genetic makeup identify probands or index cases (sample of indv that who have been diagnosed w/ a psychopathology), then study the relatives to see if they have a predisposition . the first deg. relatives would have a higher rate of the disorder vs. the general pop. 2) the twin method involves comparison btw. monozygotic (mz) twins and dizygotic twins (dz) mono=identical; share 100% genetic background di=fraternal; share 50% of genetic background like regular siblings find diagnosed cases then look to see if the other twin has the same disorder; the concordance (having the same characteristic) rate for the diagnosis should be higher in mz twins in comparison to dz ((cid:224) shows it is heritable)
