PSYC62H3 Chapter Notes - Chapter 13: Arvid Carlsson, Bipolar Disorder, Reserpine
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Alzhei(cid:373)er"s is (cid:374)ot (cid:272)o(cid:374)sidered a (cid:373)e(cid:374)tal illness because it derives from a clear, organic clause despite clear changes in mental functioning: depression, major depressive disorder disorder characterized by at least five depressive symptoms that last 2 weeks or longer. Mdd episode (cid:271)efore the first o(cid:272)(cid:272)urre(cid:374)(cid:272)e of parki(cid:374)so(cid:374)"s s(cid:455)(cid:373)pto(cid:373)s: antidepressant drugs. In the brain, pns, and intestinal tract: maob, brain and pns, serotonin and norepinephrine. Iproniazid became known as first clinically used antidepressant drug among the mao inhibitors: mao inhibitors produce antidepressant effects by binding to mae and preventing it from breaking down monoamine neurotransmitters. Maoa by tyramine: reversible, by allowing maoa to break down tyramine, Mao inhibitors: avoids chees reaction, antagonist for cholinergic muscarinic receptors, adverse effects, occur from drugs binding to various receptors in the nervous system. Its estimated that 29-46% of patients fail to fully recover with antidepressant drug treatment. Pfc: activates a protein kinase called mammalian target of rapamycin which is normally abbreviated as mtor.
