PSYB65H3 Chapter Notes - Chapter 16: Excitotoxicity, Reinnervation, Caudate Nucleus
Document Summary
Occurs when there is a failure to maintain homeostasis. The membranes of the organelles and vesicles also burst along with the membrane encasing the neuron. This bursting is called lysis and it spills all the contents of the neuron into the extracellular fluid death of the neuron. Mostly it is called by sudden injuries, disruption to the ion channel and from infections. Can also occur following damage that accumulates slowly like from neurodegenerative diseases. Ischemia: disruption in blood flow resulting from a stroke or cva, associated with disruptions in the energy pathways of neuron, which in turn can affect the ion channels, reduce or terminate atp production in neurons. This in turn will result in the stoppage of sodium potassium pump. And thus the inability to regulate sodium-potassium levels following an action potential. Stop atp production stop na+ k+ pump inability to regulate na+ and k+ levels: disruption in regulating calcium and water.
