BIO130H1 Chapter : Pg. 1071-1080.docx
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BIO130H1 Full Course Notes
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5 stages of mitosis: protophase, prometaphase, metaphase, anaphase and telophase. M-cdk drives early stage of mitosis; accessory of mitotic spindle to ensure that sister chromatin and chromosome condensation. Dephosphorlyation activates m-cdk at the onset of mitosis. Long dna molecule are pulled together at the end of s phase. Interpolar microtubule: plus end interact with each other. Mitotic spindle: array of microtubules that separate the sister chromatins. Kinetochore microtubule: are attached to the sister chromosome. Microtubule-dependent motor proteins govern spindle assembly and function. 4 types of motor protein: kinesin-5, kinesin-14, kinesin-4 and 10 and dynesin. Kinesin-5 contains 2 motor domain interact with the plus end. Kinesin-14 contains single motor: minus end directed. Kinesin-4 and 10 are plus end directed. Two mechanisms collaborate in the assembly of a bipolar mitotic spindle. Two spindles and plus ends interacting with each other. Centrosome duplicates occurs early in the cell cycle.