BIO220H1 Chapter Notes - Chapter 2: Antimicrobial Resistance, Dna Replication, Antibiotics

23 views1 pages
20 Apr 2012

For unlimited access to Textbook Notes, a Class+ subscription is required.

BIO220 Lab Chapter 2 Evolution of Antibiotic Resistance Notes
Bactericidal antiobiotics inhibit DNA replication and repair, impeding synthesis of
cell walls and membranes
Bacteriostatic antiobiotics impede replication of bacteria by interfering with protein
Bacteria express genes that reduce its sensitivity to antibiotics
Anti-biotic resistance genes interfere with antibiotic’s ability to successfully bind to
target site of bacteria, producing enzymes that inactivate the antibiotic, or reducing
the uptake of the antibiotic by the bacteria
Antibiotic-resistance genes obtained by mutation or horizontal gene transfer
To control resistance: reduce amount of antibiotics prescribed
Mutations that confer antibiotic resistance have associated fitness costs, such as
reduced growth rate
Escherichia coli
Antibiotics to treat infections of harmful E.coli (streptomycin)
E.coli evolved resistance to streptomycin via point mutation in rpsL gene
Notes from “Persistence of antibiotic resistant bacteria”
Resistance mutations unusually confer a fitness cost, alter and impair targets that
perform essential functions
Some resistance mutations confer no measurable cost
Unlock document

This preview shows half of the first page of the document.
Unlock all 1 pages and 3 million more documents.

Already have an account? Log in

Get access

$10 USD/m
Billed $120 USD annually
Homework Help
Class Notes
Textbook Notes
40 Verified Answers
Study Guides
1 Booster Class
$8 USD/m
Billed $96 USD annually
Homework Help
Class Notes
Textbook Notes
30 Verified Answers
Study Guides
1 Booster Class