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NESC 3180 (6)

October 15th, 2012

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Dalhousie University
NESC 3180
Shelly Adamo

October 15th, 2012 October-15-12 12:31 PM Acute stress and immunosuppression  With acute stress the picture is murky, not all about immunosuppression  Delayed type hypersensitivity increases o Cell mediated local immune responses, might be what you need if you have a wound incurred from a fight  During acute stress, shift of immune responses away from systemic immunity to peripheral immunity o So you're somewhat depleting your central immune resources to boost your responses in your periphery o So you're more able to protect from wounding, but less able to protect from more central diseases and infections  Dhabhar's argument Shift in focus  WBC redistribution, not decrease  Increase in peripheral t cells, nk cells, and macrophages  Migration of macrophages to skin  Found that kids being given vaccine that were stressed before hand, had more antibodies to the vaccine produced  So in essence, acute stress can help improve local immune response More trade-offs  Dhabhar - trade off between systemic and peripheral immunity  Lack of resources also part of the reason, stress very energetically expensive  Evidence in insects o Conflict between lipid transport (molecule needed to ferry lipid around) and immune function (needs the same molecule, only so much of it to go around) Lipid transport in orthoptera  apoLpIII, under normal conditions, is usually in free, uncombined form o There's a lipid carrier molecule (HDLp), picks up lipid from fat body, and shuttles it to muscle  Lipid needs carrier molecule because it's not water soluble  During times of stress o Muscles call to fat body for more fat, but carrier molecule can't handle it all at once o So ApoLpIII joins with it to form LDLp, and this new particle can carry much larger volumes of lipid o The decrease in AloLpIII floating in the blood causes problems because  Under normal conditions it's in the blood looking for bacteria, and when found, it
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