BIOL 201 Lecture Notes - Lecture 17: Tubulin, Conformational Change, Myosin
Document Summary
Long range transport is driven by motor proteins. Transport can be activated or inhibited by signaling molecules. Color of skin of the animal (darker/ lighter) Vesicles are bound to the protein that can carry. Microtubules are the roadways for the transport of organelles. Organelles are moving back and forth, up and down to the axon. Motor protein: carry things across the distances on the microtubules roadways. How to move cell inwards towards nucleus and move outside of the cell. Select whether to send cargo in or out. How do you choose which cargo to transport. Kinesin is a motor protein that walks to the microtubule plus- end. Part that hydrolyzes atp and binds to microtubule. Walks one foot in front of the other towards microtubule ends. Kinesin and myosin share a catalytic core that hydrolyzes atp. Converts that atp hydrolysis into large scale conformational changes. Kinesin encounters the microtubules with adp in both heads.
