MIMM 211 Lecture Notes - Lecture 24: Cryptococcus Gattii, Paracoccidioides Brasiliensis, Penicillium Marneffei

• School: McGill University
• Department: Microbiology & Immunology
• Course: MIMM 211
• Professor: Benoit Cousineau

Document Summary

Hypersensitivity: allergy: fungal antigens can cause allergic reaction. Ige hypersensitivity: spectrum: life threatening antigens to vanilla, asthma, rhinitis, pneumonitis, sinusitis, many molds implicated, ex. aspergillus. Asthma: normal lungs inhale aspergillus: cilia pushes spores out, so ur good, but if you have pre-existing airway disease, like cf, chronic lung disease, smoking, etc: spores stay there, form hyphae in your lungs. But can"t enter rest of body, bc immune system is fine unless allergic bronchopulmo asper rxn: ex. Usually antigen-bound ige binds mast cells to activate them, but hyphae can directly induce/turn on mast cells. Classification by symptoms: superficial, common, benign (cosmetic, not dangerous, often seen in immunocompetent people. Invasive: rarer, severe, lethal if untreated, mostly in immunocompromised patients (except dimorphic fungi) Yeasts: small, boring, round, oversized bacteria but there"s a lot of them, symptoms are similar to bacteria disease, pulmo disease is absent or subclinical, important dissemination to systemic disease, ex. Candida albicans (#1 fungus, causes candidiasis: ex.