MIMM 214 Lecture 6: Innate Immunity II: Basics, Phagocytosis & Migration

• School: McGill University
• Department: Microbiology & Immunology
• Course: MIMM 214
• Professor: Claire Trottier

Document Summary

Basics, phagocytosis & migration: pathogen entry and local inflammation. Innate immunity: primary line of disease, mostly mediated by leukocytes other than lymphocytes. Immediately available in an immune response: phagocytes, macrophages and its tissue specific variants, granulocytes (e. g. neutrophils) Immature dendritic cells: natural killer (nk) cells, does not get better with exposure (no memory, no fine specificity. Take-home message: pathogens enter through mucosal and epithelial surfaces - different routes, mouth/respiratory, gi tract, reproductive tract, many types of pathogens, extracellular and intracellular. Innate immunity: tissues and physical elements: epithelial surfaces of the body provide the first barrier against infection, skin, gut epithelium, respiratory epithelium, problems with these barriers increases risk of infection. Saliva, hair, mucus, tears --> all provide innate immunity. Innate immunity: cellular elements: neutrophils and other granulocytes, contain granules; different granulocytes have different components in the granules, monocytes and macrophages, tissue-specific variants: kupffer cells, microglia, intraglomerular mesangial cells, etc, dendritic cells.