MIMM 214 Lecture Notes - Lecture 36: Allergic Rhinitis, Immunoglobulin Class Switching, Mast Cell
7 Jun 2018
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Lecture 37 – April 7, 2017
Allergies
Recall Th2 effector functions
- Secrete IL-13, IL-4, IL-5
- Smooth muscle cell contraction
- Recruit eosinophils and mast cells
Allergies
- Combination of genetics and environment
o Hygiene hypothesis
- Must be exposed to non-dangerous non-self, and somehow trigger an immune response
- Atopy
o Eczema
o Allergic rhinitis
o Asthma
- Airborne allergens are frequently the cause of allergies
- Share certain characteristics
- Examples
o Pollen
o Pet dander
o Molds
Sensitization and immediate hypersensitivity reaction
- Exposure to common respiratory allergen
- Th2 response is generated and isotype switching results in IgE secretion
- IgE binds Fc receptors on mast cells in tissue
o They will stay in tissues
- Upon subsequent exposure, mast cells can degranulate when their Fc receptors are crosslinked
by Ag binding to Abs
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