MIMM 214 Lecture Notes - Lecture 16: Immunoglobulin Light Chain, Oligomer, Ikea

• School: McGill University
• Department: Microbiology & Immunology
• Course: MIMM 214
• Professor: Joaquin Madrenas

Document Summary

Intervening dna between v/j or v/d/j loops out to be excised and degraded. The v/j or v/d/j become one transcriptional unit. The c gene follow the v domain. Predicted total diversity of igs = 5 x 1013. (predicted total diversity of tcr = 1018) Problem: 20,000 25,000 protein-coding genes in humans. Need to rearrange genes to form diversity. Modularity of the ikea model allows finite number of protein coding genes to be able to generate almost infinite possibilities of combination. 1 allele codes for the l chain. 1 allele codes for the h chain. For l chain: specific v gene/j gene combination. For h chain: specific v gene/d gene/j gene combination. C domains of the ig molecule = c genes. Room for error at the nucleotide level at the end of the v gene and at the beginning of the j gene allows the excision to be slightly off.