PARA 438 Lecture Notes - Lecture 19: Autoimmune Disease, Cd28, Clonal Anergy
5 Nov 2018
School
Department
Course
Professor
Document Summary
Tolerance: mechnism to protect one individual from portntially self-reacting lymphocyte. Central tolerance: primary mechanism, delete tc / bc before maturation if they posses r that recognize self ag with greater than a threshold affinity. Peripheral tolerance: render lymphocyte in secondary lymphoid tissues inactive/anergic. Apc binds mhcii + tcr binds co-stimulatory b7 + cd28. Anergy: apc binds mhcii + tcr, cd28 alone, no co-stimulatory b7. Characteristic of anergy: unable to make il2, and can"t stimulate proliferation. Co-stimulatory b7 + cd 28 alone, tcr, no mhcii ---no effect on tc. Autoimmunity : system of immune responses of an organisms against self ags. Autoimmune reactions; can cause serious damage to cells / organs leading to death. Although generally autoimmune disease is mediated by b+ tc, but all aspects of immune system plays a role. In sle, tc helps bc to make autoantibody / bc present self-ag to t (cd4-mhcii) and the ab plays a role in pathology.
