BIOCHEM 2EE3 Lecture Notes - Lecture 10: Conformational Change, Pyruvate Dehydrogenase, Phosphate

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15 Mar 2017

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There is still energy packed away in those electrons that were passed on to nadh and fadh2. Nadh and fadh2 will donate they electrons to the electron transport chain. The chain is made up of five protein complexes which are embedded in the inner mitochondrial membrane. Named protein complex i, ii ,iii, iv, and v. The role of the first protein complexes is two fold: to accept electrons and shuttle them along, to pump protons out of the mitochondrial matrix into the intermembrane space. There are two electron carriers, coenzyme q and cytochrome c which shuttle the electrons between protein complexes. This is because electrons do not diffuse well on their own through the membrane. Coenzyme q and cytochrome c are lipid soluble. Within each protein complex there are several redox centres which can be reversibility reduced and re-oxidized like nadh and fadh2. These redox centres can be categorized as: coenzymes, fe-s clusters, cytochromes, cu.

Related Questions

The glycerol-3-phosphate shuttle can transport cytosolic NADH equivalents into the mitochondrial matrix (see Fig. 15.11c). In this shuttle, the protons and electrons are donated to FAD, which is reduced to FADH2. These protons and electrons are subsequently donated to coenzyme Q in the electron transport chain. Given that the number of ATP molecules made per NADH and FADH2 oxidation differ by ____? the amount of ATP generated per mole of glucose when the glycerol-3-phosphate shuttle would be ____ instead of 32.

19. Which of the following is a component of Succinate dehydrogenase in Electron transport chain?

A. Niacin

B. FMN

C. FAD

D. Coenzyme Q

E. Lipoic acid

20. In electron transport the flow of electrons:

A. is bidirectional

B. goes from a high energy state to a low energy state

C. takes place in the outer mitochondrial membrane

D. are used to pump H+ into the mitochondrial matrix

21. Which of the following statements about the electron transport chain is NOT correct

A. It is located in the inner mitochondrion membrane

B. Cytochrome c accepts electrons from complex II

C. Cytochrome c oxidase (complex IV) accepts electrons from Cytochrome c

D. Complex I is called NADH dehydrogenase

E. Coenzyme Q accepts electrons from complex I and complex II

22. In the electron transport chain, the enzyme cytochrome C oxidase:

A. Uses H2O as a substrate

B. Produces HOOH as a product

C. Cannot function if oxygen is absent

D. Accepts electrons from hydrogen ions

E. Uses ADP and Pi as substrates

Oxidative phosphorylation is the final stage of cellular respiration and the main pathway of aerobic energy generation from glucose. Which of the following statements is NOT true?

a. NADH and FADH2 are used as âinputâ into the electron transport chain

b. The electron transport chain produces a proton gradient across the inner mitochondrial membrane

c. FADH2 stores less energy than NADH

d. The electron transport chain is made up of several membrane protein complexes

e. ATP synthesis by chemiosmosis requires about 30 protons per ATP molecule

BIOCHEM 2EE3 Lecture Notes - Lecture 10: Conformational Change, Pyruvate Dehydrogenase, Phosphate

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