MICR 360 Lecture Notes - Lecture 2: Cytotoxic T Cell, Innate Immune System, Amphiphile
22 Dec 2018
School
Department
Course
Professor
Document Summary
More effective w gram +ve bacteria (no om so pg more exposed) Evol conserved peptides, amphiphatic w hydrophobic regions, act w/n minutes to create leaky memb: attachment: rs bind microbes. Opsonization: bacteria coated w antibodies binds fc rs, specific opsonin= antibody, non specific=c3b. Opsonins: macromolecules rec by surface rs on phagocytes, increases phagocytosis efficiency: ingestion of bacterium forms phagosome, fusion: phagosome + lysosome, digestion, release of digestion prod. Interaction: dendritic bridge the 2 sys (bring antigens from infection to t cells) act t cells diff into pathogen-specific subsets opsonization, complement act. Antigen transported to lymphoid organs b + t cell rec clonal expansion + differentiation to effector cells. Specificity: distinct microbes elicit specific b and t cell act. Diversity: b + t cells can respond to very large variety of microbes. Self-limitation: microbe-act immune responses to return to its basal state (homeostasis) Physical barriers skin, gut villi, pulmonary cilia n/a. Immediate, germline encoded rs, not antigen specific, no memory.
