PHAR 100 Lecture Notes - Cholesteryl Ester, Hyperlipidemia, Very Low-Density Lipoprotein

• School: Queen's University
• Department: Pharmacology and Toxicology
• Course: PHAR 100
• Professor: Hisham Elbatarny

Document Summary

Most troublesome: coronary and cerebral arteries accumulation of fatty plaques (atheroma) on the inside wall of arteries: -oma: mass due to hyperlipidemia: elevated lipid concentration in blood, most common cause of cad. Rough patch : thrombosis on top which can eventually block vessel. Main plasma lipids cholesterol (c) cholesterol esters (ce) triglycerides (tg): most abundant phospholipids. Cholesterol: white waxy material component of, steroid hormones (cholesterol = precursor, vitamin d, bile salts, cell membrane. Triglycerides: most abundant lipid in the body structure, glycerol + 3 fatty acids. 2 sources: exogenous: from diet, endogenous: made in the body. Cholesterol: red stars size (increasing) mass (increasing) cholesterol: tg ratio elsewhere in body) Classification of lipoproteins chylomicrons very low density lipoproteins (vldl) intermediate density lipoproteins (idl) low density lipoproteins (ldl) high density lipoproteins (hdl) Characteristics of lipoproteins chylomicrons: largest size of lipoproteins, formed in the intestine, carry exogenous tg, vldl, formed in the liver, carry endogenous tg.