PHAR 100 Lecture Notes - Lecture 22: Selman Waksman, Gerhard Domagk, Prokaryotic Small Ribosomal Subunit

• School: Queen's University
• Department: Pharmacology and Toxicology
• Course: PHAR 100
• Professor: Nikki Philbrook

Document Summary

Describe the properties of selected penicillins, cephalosporins, ciprofloxacin, erythromycin, Discuss the rationale for the combination of trimethoprim with sulfamethoxazole. Describe the advantages and disadvantages of the use of antibiotic combinations. 1909: paul ehrlich introduced the concept of chemotherapy and designed organoarsenical drugs on rational grounds, and provided a cure for syphilis in the early 20th century. 1929: alexander fleming worked at st mary"s hospital in london and found staphylococcus aureus growing on a petri dish close to penicillium mould. He saw that the mould secreted something (penicillin) that inhibited the growth of the bacteria. 1935: gerhard domagk introduced sulfonamide drugs in germany which were efficacious against bacterial diseases that were severe. 1939-1945: during wwii florey and chain at oxford isolated penicillin for gram-positive bacteria. 1943: selman waksman at rutgers university in the us introduces streptomycin which treated tuberculosis and other gram-negative bacteria. Antibiotic: chemical substance produced by microorganisms that suppresses the growth of other organisms and may destroy them.