BIOCH200 Lecture Notes - Pyruvate Dehydrogenase Complex, Pyruvate Dehydrogenase, Lactate Dehydrogenase
10 Apr 2014
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Bioch 200 glucose metabolism (april 4, 2014: why does pyruvate require anaerobic fate, so it can be used to produce useful compounds even in the absence of oxygen. Ex. lactate (not an acid) via lactate dehydrogenase. *a dead-end product that has no useful purpose in muscle tissue that is: *lactate can be used as metabolic fuel for cardiac muscles. Nadh which can now travel to the etc. 2) converted to acetyl-coa and co2: this reduces another nad+ into nadh. Then it is oxidized by cac (citric acid cycle: glycolysis produces, 2 pyruvate, 2 nadh, net yield of 2 atp molecules. *pyruvate acetyl coa (aerobic pathway of pyruvate: *catalyzed by pyruvate dehydrogenase complex (pdh) *oxidative decarboxylation (which is actually just oxidation and decarboxylation) Is a multienzyme complex with many copies of three catalytic enzymes that are responsible for catalyzing decarboxylation, transfer of coa, and oxidation.
