MBIO 2360 Lecture Notes - Lecture 11: Atorvastatin, Sildenafil, Enzyme Kinetics
1 Dec 2016
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Enzymes can also go backwards, make product into substrate. Thus, enzymes provide a special environment in which bond formation/breakage is easier: example - consider the hydration of co2 to produce bicarbonate, formula. Lots of g must be added to stretch the bonds to the point of breaking in order to drive the reaction. Graph: the reaction is catalyzed by carbonic anhydrase. This is 106 times faster than the uncatalyzed reaction. Note, the keq is not affected by a catalysis. If the enzyme increases the forward rate k1, then the back rate k2 will also be increased. Binding energy is also used for: entropy reduction. Hold the substrates close together in proper orientation for reaction. But you get the plus from all the favourable reactions with the e and s: desolvation. Substrate molecules are surrounded by a water hydration shell that must be removed for reactions to occur.
