MBIO 2370 Lecture Notes - Lecture 5: Pyruvate Decarboxylase, Citric Acid Cycle, Allosteric Regulation

80 views2 pages

grayrabbit360

7 Feb 2017

School

University of Manitoba

Department

Microbiology

Course

MBIO 2370

Professor

Dr.Peter Pelka

For unlimited access to Class Notes, a Class+ subscription is required.

Document Summary

In the etc - the many different cofactors in the complexes are used to pass the electrons through the complex: find out the number for f. Regulation is necessary due to interconnection of pathways. High energy molecules signal a slow down of glycolysis and the tca cycle and turn on gluconeogenesis. Low energy molecules signal an increase in glycolysis and the tca cycle. If you have a lot of accoa, you might need more oaa to keep the cycle going. This is all regulation at enzyme level: allosteric regulation, quickest way, most efficient way for multiple pathways throughout the cell. High energy signals - atp, nadh, citrate. Pfk reaction is irreversible and this requires a separate enzyme to catalyze reverse reaction (frc. Can affect the reverse enzyme to make it go the other way. High energy molecules signal a slowdown in energy production: high energy signals - atp, nadh, citrate, allosteric effect in pfk regulation.

Related Questions

A catabolic pathway would predictably result in the
A) reduction of a sugar.
B) synthesis of a macromolecule.
C) breakdown of a macromolecule.
D) breakdown of an atom.
2.
The drug Ritonavir is used to treat people with HIV/AIDS. It worksby binding to the active site of HIV-1 protease, an enzyme used bythe AIDS virus to create new proteins for production of newviruses.Once bound, the HIV-1 protease cannot produce proteins.Ritonavir can be classified as a(n)
A) competitive inhibitor.
B) allosteric inhibitor.
C) activator.
D) non-competitive inhibitor.
3.
During cellular respiration, __________ is the final electronacceptor that allows the regeneration of the cellâs supply of NAD+.In fermentation, ____________ is the final electron acceptor forNAD+ regeneration.
A) pyruvate / lactic acid
B) pyruvate / oxygen
C) ethanol / CO2
D) oxygen / pyruvate
4.
Which of the following clues would tell you if a cell isprokaryotic or eukaryotic?
A) whether or not the cell carries out cellular metabolism
B) the presence or absence of ribosomes
C) whether or not the cell is partitioned by internalmembranes
D) whether or not the cell contains DNA
5.
Phosphofructokinase (PFK) is an allosteric enzyme that regulatesglycolysis. When cellular concentrations of ATP and citrate become__________, this enzymeâs activity decreases. When cellularconcentrations of AMP become ________, the enzyme isactivated.
A) high / high
B) high / low
C) low / high
D) low / low
6.
______________ is an enzyme that can utilize the free energy in thehydrogen gradient (voltage) produced between the inner and outermembrane of the mitochondrion. The enzyme uses this energy toproduce ________.
A) ATP synthase/ ATP
B) PFK/ ATP
C) PFK/ glucose
D) ATP synthase/ ADP
7.
ATP is able to do cellular work because it
A) has a high energy phosphate bond that can be hydrolyzed torelease energy.
B) converts light energy into chemical bond energy.
C) contains the sugar ribose, which can provide additional energyfor a cell.
D) its hydrolysis is endergonic.
8.
A solution of starch at room temperature does not readily decomposeto form a solution of simple sugars because
A) the starch solution has less free energy than the sugarsolution.
B) the activation energy barrier for this reaction cannot besurmounted.
C) the hydrolysis of starch to sugar is endergonic.
D) starch hydrolysis is nonspontaneous.
9.
A person exposed to toxins would have more activity in their___________compared to an unexposed person.
A) lysosomes
B) Golgi bodies
C) rough endoplasmic reticulum
D) smooth endoplasmic reticulum
10.
Which of the following statements about fermentation is true?
A) The function of fermentation is to regenerate the fermentingcells' supply of NAD+.
B) Fermentation allows a fermenting cell to gain more energy perglucose molecule than a non-fermenting cell.
C) Fermentation produces either lactic acid or ethanol that thefermenting cell can use as an energy source.
D) Fermentation is a universal process that occurs in all cells andall organisms.
11.
A glucose molecule is completely broken down to carbon dioxide andwater in glycolysis and the citric acid (Krebs) cycle, but togetherthese two processes yield only a few molecules of ATP. Whathappened to most of the energy that the cell obtains from theoxidation of glucose?
A) It was lost as heat.
B) It is stored in the carbon dioxide and water molecules releasedby these processes.
C) It is stored in the ATP that was formed by glycolysis and thecitric acid cycle.
D) It is stored in NADH and FADH2
12.
The First Law of Thermodynamics states that
A) entropy tends to increase in a system.
B) entropy tends to decrease in a system.
C) energy cannot be created nor destroyed.
D) the quality of energy in the universe is decreasing.
13.
The endosymbiotic theory states that _______________ evolved as aresult of a symbiotic relationship between different types ofbacteria. _____________ is thought to be the selective factor thatmade this symbiosis advantageous.
A) mitochondria / A change in the Earthâs atmosphere from anaerobicto aerobic
B) endoplasmic reticulum / A decrease in the amount of foodavailable in the environment
C) chloroplasts / A change in the Earthâs atmosphere from aerobicto anaerobic
D) lysosomes / A decrease in the amount of food available in theenvironment
14.
A mutation in a fruit fly affects one of the proteins that pumphydrogen ions across the inner mitochondrial membrane; thismutation makes that particular protein function less efficiently.When comparing aerobic cellular respiration in this fly with awild-type fly, you would predict that the mutant fly would
A) produce less ATP than a wild-type fly.
B) show no difference in ATP production when compared to awild-type fly.
C) produce more ATP than a wild-type fly.
D) not be able to produce any ATP via aerobic cellularrespiration.
15.
Proteins that are destined to be exported from the cell have unique_________________ that are recognized by signal recognitionparticles and thus moved to the _________________ duringtranslation.
A) phosphofructokinases / nucleus
B) codons / rough endoplasmic reticulum
C) signal recognition sequences / rough endoplasmic reticulum
D) signal recognition sequences / free ribosomes
16.
During the Krebs cycle
A) NADH is oxidized.
B) ATP is produced.
C) pyruvate is produced.
D) Acetly CoA gains a carbon to form pyruvate.
17.
Why does the oxidation of organic compounds by molecular oxygen toproduce CO2 and water release free energy?
A) Electrons are being moved from atoms that have a lower affinityfor electrons (such as C) to atoms with a higher affinity forelectrons (such as O).
B) The electrons have a higher potential energy when associatedwith water and CO2 than they do in organic compounds.
C) The covalent bond in O2 is unstable and easily broken byelectrons from organic molecules.
D) The covalent bonds in organic molecules and molecular oxygenhave more kinetic energy than the covalent bonds in water andcarbon dioxide.
18.
In a chemical reaction, if ?G is negative, it means that thereaction is
A) exergonic, and work needs to be done for the reaction toproceed.
B) exergonic, and work can be done with energy released from thereaction.
C) endergonic, and work needs to be done in order for the reactionto proceed.
D) endergonic, and work can be done with energy released from thereaction.
19.
The energy for an endergonic reaction comes from a(n) ___________reaction.
A) ADP + P --> ATP
B) endergonic.
C) exergonic.
D) anabolic
20.
Glycolysis
A) involves catabolic reactions and ATP is produced.
B) involves anabolic reactions and ATP is produced.
C) involves catabolic reactions and creates energy.
D) involves anabolic reactions and creates energy.

MBIO 2370 Lecture Notes - Lecture 5: Pyruvate Decarboxylase, Citric Acid Cycle, Allosteric Regulation

Document Summary

Get access

Related Documents

MBIO 2370 Lecture Notes - Lecture 9: Transamination, Tyrosinase, Tetrahydrofolic Acid

MBIO 2370 Lecture Notes - Lecture 3: Phosphoenolpyruvate Carboxykinase, Pyruvate Carboxylase, Anaplerotic Reactions

MBIO 2370 Lecture Notes - Lecture 4: Electron Acceptor, Cytochrome C Oxidase, Nadh Dehydrogenase

Related Questions