MBIO 3410 Lecture Notes - Lecture 1: Central Dogma Of Molecular Biology, Alternative Splicing, Deamination
24 Dec 2015
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Document Summary
Rna world ribozymes (cid:2) (cid:2) (cid:2) (cid:2) (cid:2: rna viruses. Dna promoter sequences (cis acting elements) and other sites that. Trans acting factors (regulatory proteins, rna molecules) can affect: spontaneous deamination or via nitrous acid. Rna can tolerate uracil because its half-life is much shorter; turned over very quickly. 2"oh group on rna makes it susceptible to alkali conditions. Nucleoside: sugar (ribose or deoxyribose) and nitrogenous base. Nucleotide triphosphates have , , and phosphates: dna or rna"s negative charge due to phosphate groups. Dna structure: double-stranded, antiparallel orientation of two polymers. Double helix stabilized by hydrogen bonding and hydrophobic interactions. Protein-dna interactions usually take place in the major groove. Rna can form short, helical regions (hairpin loops), and even fold into complex tertiary structures. Regulation riboswitches and attenuation; folding can influence trna, rrna, ribozymes (cid:2) (cid:2) speed of translation. How rna folds affects speed of translation. Folds in mrna affect translated protein structure and folding.
