PHA 3112 Lecture Notes - Lecture 6: Angiotensin Ii Receptor Blocker, Sick Sinus Syndrome, Ace Inhibitor

• School: University of Ottawa
• Department: Pharmacology
• Course: PHA 3112
• Professor: Pierre Fortier

Document Summary

Reduction of blood volume & 2) reduction of arterial resistance. 536: lec 1 ch 2 (5. 5) pages left: hydrochlorothiazide: Principal adverse effect: hypokalemia = reduce by eating potassium-rich foods & potassium supplements or a potassium-sparing diuretic. Preferred doc cuz = superior to calcium channel blockers & ace inhibitors: furosemide {lasix]: Furosemide is a high-ceiling diuretic that produce greater diuresis than thiazide; amount of fluid loss produced is greater than needed or desirable = not used routinely. Most adverse effects: hypokalemia, dehydration, hyperglycemia, & hyperuricemia; & hearing loss: spironolactone [aldactone] Spironolactone is potassium-sparing agents that induced diuresis is small; only modest hypotensive effects. Ability to conserve potassium = play imp role in antihypertensive regimen. They can balance potassium loss caused by thiazides or loop diuretics. Most significant adverse effect: hyperkalemia. blockers, or aldosterone antagonists: metoprolol, propranolol [inderal] Adverse effects: blockade of cardiac beta1 receptors can cause bradycardia, decreased atrioventricular (av) conduction, & reduced contractility.