Notes taken during lecture

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13 Jan 2011
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LECTURE 01
11 – cells can move, proteins in cytosol can move and interact with each other, vesicles also move from
different compartments in cell to cell surface
13 – know Golgi, endoplasmic and what they do
Secretion of cell – extracellular matrix – so cells migrate by crawling along
Lysozome – membrane bound acidic compartment – digestion of things cell
Endoplasmic reticulum – rough ER has ribosomes docked there
Proteins translated into lumen – proteins into golgi apparatus – where enzymes modify and sort proteins
into different vesicles, which then go to proper components into cell
Smooth ER where membrane components are synthesized
14 – vacuole – two types – storage unit where macromolecules stored – versus lysosome involved in
degrading etc.
Tonoplast is the membrane of vacuole
15 Cytoplasm – space outside of nucleus, including organelles
Cytosol – aqueous part of cytoplasm
Lumen – aqueous part inside organelles
Nucleoplasm – aqueous part of nucleus
18 – divide cell from extracellular space
Eukaryotic cells have membranes into even smaller compartments/organelles, where there are different
concentrations of ions, - compartmentalizations mean specialization of cell, of regions in cell
Between cytosol, organelles, extracellular environment
Membranes must be slightly different from each other – unique membrane so contents are unique
19 Plasma membrane
Nuclear membrane – lumen of ER and nucleus is the same
Rough ER – continuous with smooth ER
Smooth ER
On right side from bottom up – Golgi apparatus, lysosome (containing acid hydrolases), vesicle,
mitochondrion (with two membranes)
20lipid bilayer – basic unit; fluid structure
Membrane proteins – transport proteins; receptors
21 – amphipilic – hydrophilic or polar head group (red ball) – stable when interacting with water
molecules ; hydrophobic or nonpolar tail (thermodynamically stable to be tucked in interior of bilayer,
unstable when exposed to water or cytosol)
>>>22 – Lumen
Lumenal
Vesicles deliever luminal phase to extracelluar
Some enzymes exist in lumen of the Golgi or cytoplasm, so will affect their final location
23 – spontaneously self-associate into bilayer
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Document Summary

11 cells can move, proteins in cytosol can move and interact with each other, vesicles also move from different compartments in cell to cell surface. 13 know golgi, endoplasmic and what they do. Secretion of cell extracellular matrix so cells migrate by crawling along. Lysozome membrane bound acidic compartment digestion of things cell. Endoplasmic reticulum rough er has ribosomes docked there. Proteins translated into lumen proteins into golgi apparatus where enzymes modify and sort proteins into different vesicles, which then go to proper components into cell. 14 vacuole two types storage unit where macromolecules stored versus lysosome involved in degrading etc. 15 cytoplasm space outside of nucleus, including organelles. Eukaryotic cells have membranes into even smaller compartments/organelles, where there are different concentrations of ions, - compartmentalizations mean specialization of cell, of regions in cell. Membranes must be slightly different from each other unique membrane so contents are unique. Nuclear membrane lumen of er and nucleus is the same.

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