BIO120H1 Lecture : Notes taken during lecture

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redtermite204

2 Feb 2011

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Intracellular vesicular transport part 1 and molecular mechanisms. Proteins today all synthesize into er lumen or. Golgi has series of membrane stacks/pancakes there are resident proteins in each stack. ceramide more minor component made in er transported to other compartments in vesicles: synthesized in er, transported into golgi, where it is modified to produce. glycolipids sugars attached to fat happens in golgi. Do not need to memorize the chemical pathway. enzymes labelled in green in cytosol or are transmembrane membranes with acive sites in cytosol. occurs in cytosol *** cytosolic leaflet will grow, made by er expansion : plasma membrane expands lipids from er, new lipids in cytosolic leaflet of er . Newly synthesized lipids inserted into cytosolic leaflet luminal leaflet a bit smaller not stable so some lipids in cytsolic leaflet flipped into other leaflet. scramblase : so random distribution in er membrane.

Related Questions

29 Most proteins destined to enter the endoplasmic reticulum _________.

(a) are transported across the membrane after their synthesis is complete.

(b) are synthesized on free ribosomes in the cytosol.

(d) are keep binding to Signal recognition particle (SRP) while they are translated.

30 Which of the following choices reflects the appropriate order of locations through which a protein destined for the plasma membrane travels?

(a) lysosome â endosome â plasma membrane

(b) ER â lysosome â plasma membrane

(d) ER â Golgi â plasma membrane

31 Which of the following statements about vesicle budding from the Golgi is false?

(a) COPII can initiate vesicle budding on Golgi membrane.

(b) Some vesicles budded from Golgi membranes move towards ER.

(d) Clathrin molecules act at the cytosolic surface of the Golgi membrane.

32 Which of the following statements is false?

(a) The signal sequences on mitochondrial proteins are first bound to translocator on outer membrane after translation.

(b) Most mitochondrial proteins are not imported from the cytosol but are synthesized inside the mitochondria.

(c) Chaperone proteins in the mitochondria facilitate the movement of proteins across the outer and inner mitochondrial membranes.

(d) Mitochondrial proteins cross the membrane in their unfolded state.

orangeplatypus673

In the plasma membrane of erythrocytes the concentration ofphosphatidylserine on the extracellular side of the membrane is2.32 microM while on the cytosolic side its 615.56 microM. Thetransmembrane potential is -70 mM (extracellular --> cytosolic)and the free energy change associated with this transversediffusion is 21.14 kj/mol.

(C) ( 2 pts) Name the protein that transports phosphatidylserinefrom the extracellular side of the membrane to the cytosolicside.________________________________-

(D) ( 2 pts) How does this protein make this transportexergonic?

(E) ( 2pts) This is an example of what type oftransport?___________________________________

fuchsiarhinoceros778

1- What is the role of a rER translocon?

a- Bind with a ribosome for peptide synthesis in the rER lumen.

b- Flip proteins into the cytosol.

c- Bind a signal recognition particle.

d- Proofread newly assembled proteins.

e- Terminate translation.

2- Select all of the following categories of proteins which are made (synthesized by the Rough ER).

a- Secreted Proteins (like hormones, neutotransmitters)

b- Proteins integrated into a cellâs own plasma membrane

c-Proteins integrated into a cellâs own intracellular membranes (such as the Gogli, vesicles)

d-Proteins that are dissolved in a cellâs own cytosol

tealmouse499

BIO120H1 Lecture : Notes taken during lecture

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