CSB327H1 Lecture Notes - Lecture 5: Blastocyst, Inner Cell Mass, Dapi
10 Oct 2012
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Document Summary
Epithelial cells are polarized: sit on a basal lamina, may be motile during wound repair, golgi complex is in apical cytoplasm, lateral side forms specialized junctions between cells. Mesenchymal cells are spindle shaped: reside in the ecm, may be motile, golgi complex is at leading edge, do not form specialized junctions between cells. Epithelial-mesenchymal transition (emt: epithelial cells are released from the surrounding tissue in emt. Tight junctions, adherens junctions and desmosomal junctions are dissociated. The basal lamina is sometimes dissolved by mmp to be able to transmigrate across. The new mesenchymal cells are emigrating: epithelial cells is reached with the formation of basal lamina in met, emt is easier than met. Activation of mesenchymal transformation of epithelia by 3d type i collagen gels: enzymatically digested type i collagen cannot polymerize in vitro, epithelia placed on 3d type i collagen gel.
