IMM250H1 Lecture Notes - Lecture 11: High Endothelial Venules, Thymocyte, Lymph Node
Document Summary
Lymphocyte migration and t-cell migration through the body: T-cells move from blood to lymph nodes to lymph and back to blood. Na ve t-cell enter post capulary venules (configuration of high endothelial venule, different geometry) Express adhesion molecules (attract resting naive t-cells) Stick to hev(high endothelial venules) through adhesion molecules. Hev are located in the pericortex (rich in t-cells and dcs) Sit in lymph node for 18h looking for antigen (move randomly and faster than b-cells) Memory t-cells do not enter through the hev, they enter through the. **na ve t-cells do not enter through the afferent lymphatics they enter through the hev on the adhesion molecules lymphatics (cid:523)they don"t go through blood, they go through tissues in case of infections) Experiment: peak of an immune response, very concentrated amount of t-cells in lymphoid tissues. However, after a month t-cells had moved to other locations (brain, lung in case of other infections)
