IMM250H1 Lecture : Notes taken during tutorial

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redtermite204

19 Dec 2011

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20 best answer questions, 20 multiple choice questions ** Life span of conventional b cells determined by recirculation lecture 5. During selection process, they encounter self antigens within bone marrow which is where b development takes place. After development, b cells go through negative selection process: b cells highly reactive with antigens, eliminated by clonal deletion or receptor editing process. B cell receptors crosslinked by strongly interactive self-antigens. Also situation in which b cell receptor recognize self antigen but it s affinity, not strong enough to induce neither clonal deletion or editing process: soluble self-antigen, diff from mature b cells. Induce bit of activation result in different outcome, anergy. co-expression of igm and igd is sign of mature, naive b cell. anergic cells do migrate to periphery but express low levels of igm, cannot respond to antigen even when t cell help is provided. active process of rendering cells unable to respond to antigen.

Related Questions

Which of the following statements about induction or maintenance of T cell tolerance is NOT true?

	a.	Peripheral T cell tolerance to an antigen may be induced by persistent and repeated stimulation of lymphocytes by that antigen in tissues.
	b.	Peripheral T cell tolerance results when T cells recognize antigen in the setting of an innate immune response to the antigen.
	c.	Peripheral T cell tolerance to some antigens is induced when mature T cells recognize antigen and bind B7-1 or B7-2 via the inhibitory CTLA-4 receptor.
	d.	Peripheral T cell tolerance results when mature naive T cells recognize antigens without adequate B7-1â or B7-2âmediated costimulation.
	e.	Central tolerance is induced when immature developing T cells in bone marrow or thymus encounter self-antigens.

chocolateporpoise530

indicate whether you think the statements are true or false, and explain your reasoning. In each of your answers, provide 1-2 specific examples that support your position. (Each of your four answers is worth five points):

A) Memory cells require fewer distinct signals to be activated than naiÌve cells require.

B) Both B cells and T cells undergo âclonal selectionâ after they are activated by antigen.

C) A B cell is only able to present antigen to a T cell that includes the epitope to which the

B cellâs receptor bound.

D) T cells can recognize peptide antigens in the context of MHC I and MHC II regardless of

whether they are Thelper or Tcytotoxic cells.

E) B cells and T cells can both still make productive antigen receptors via V(D)J

recombination even if no P-nucleotides are introduced during the process.

F) Allelic exclusion takes place when a naiÌve T or B cell encounters its specific non-self antigen for the first time and determines whether or not to become activated.

G) B cells have more chances to make a productively rearranged antigen receptor than T cells do.

H) A majority of immature T cells developing in the thymus will survive both positive and negative selection.

I) The reason why T cells are the only type of white blood cell that requires maturation in a specialized organ outside the bone marrow is because they are the only ones that must have antigen processed and presented to them before they can be activated.

violetbear615

1. What is the role of primary lymphoid follicles in eliminating B cells that have antigen receptors specific for soluble self antigen?

2. What is "affinity maturation"? Affinity maturation of the B cell response has been likened to a process of "Darwinian selection". Explain how so?

3. If you could produce a strain of mice in which the follicular dendritic cells of the lymphoid organs were deleted, list the differences in the humoral immune response you might expect to see.

IMM250H1 Lecture : Notes taken during tutorial

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