Class Notes (905,604)
CA (538,462)
UTSG (45,721)
IMM (197)
IMM250H1 (170)
Lecture

Notes taken during lecture

6 Pages
86 Views

Department
Immunology
Course Code
IMM250H1
Professor
J.Gommerman

This preview shows pages 1-2. Sign up to view the full 6 pages of the document.
LECTURE 7 March 1st, 2011
MIDTERM: 36 multiple choice questions; 2158 in the medical sciences building for the
tutorial
Location is the lecture room
Todays material will not be on the midterm
Anatomical context where immune responses take place in body
Movies are not testable material, just to fill in knowledge
How do lymphocytes move around the human body?
Lymphocyte migration
oLymphocytes always moving throughout body
oNeed to patrol body for infection, tumour cell growth or antigen, anything
dangerous or foreign to host
Lymphatic system network of conduits carrying lymph
oplumbing
oAnything dangerous is put into lymph nodes, where they are
interrogated
oEfferent going in
oAfferent where lymphocytes leave the nodes
Lymph interstitial fluid in tissues found between cells of body
oEnters lymphatic vessels to be sampled in the lymph nodes
Systemic infection, for example, spleen is first point of contact with immune cells
with pathogen
oSpleen filter agent for blood
oLymph nodes filter agent for lymph
Dont need all lymph nodes to control body
oMany can be absent
oIf one is absent the next one can take over the responsibilities
Migration of lymphocytes
Chemokines
T cell will move towards chemokines
T-cell chemokines different from b cell chemokines
oImportant to orchestrate cellular interactions for an immune response
Chemokines work in a gradient
oImagine a drop of colouring into water
oConcentration brightest at the source of chemokines
Lymphocytes would keep going around in blood forever
oBut most infection they deal with are in tissue beds
oSo must enter lymph nodes to check for pathogen
oThey do so by sticking to endothelial cells of blood vessels, sense a
chemokine gradient, and then squeeze through endothelial cells to get
into tissues
Proteins mediating sticking to the cells adhesion molecules
www.notesolution.com
Lymphocytes know where to jump off highway to get into lymph
nodes
At places where lymph nodes branch off from blood vessel,
elevated endothelial venules are there
oHEV so lymphocytes can enter lymph node tissue
by squeeze through endothelial cell tissue into node
oEndothelial cells raised as HEV
Lymphocyte migration no flat surface
oT-cell T-cell receptor, CD3, 4, or 8 sticking out; adhesion molecules
sticing out too; receptors for chemokine gradients sticking out too
Sensing molecules are stuck on microvilli, projections off T-
Still very effective for T-cells to interrogate their
environment
Chemokine receptors look funny adhesion receptor bind to adhesion
oDirectional cue to lymphocyte thus chemokine not cytokine
If sick and have fever, know adhesion receptors on surface of endothelial
cells are up regulated (many of them, instead of one or two)
oChemokine are more intense
oLymph node draining upper respiratory tract these lymph nodes
will increase expression of adhesion molecules and
oWant to concentrate antigen-specific Tcell to the lymph node thats
draining the site of infection
Upregulate so lymphocytes will preferentially go to this
particular lymph nodes, so can get right lymphocytes at the
right place at the right time
Fever optimize getting cells to appropriate lymph node to
get the adaptive immune response
A little fever is thus good
Naïve T-cell from blood, squeezes through HEV, and goes into lymph node tissue,
spend time in node
If everythings fine, will leave through efferent and repeat the same
If infection in tissue bed that drains the particular lymph node,
oTissue bed drains lymph into lymph node
If lymphocyte isnjt antigen specific, doesnt see anything dangerous
spend time in node and then leave through efferent lymphatic as naïve T-
oEfferent lymph collected in thoracic duct
oTwo ducts collect all lymph from body
**CORRECTION efferent and afferent on the definition page
Afferent lymphatic system drains tissue bed
Naïve lymphocyte doesnt go into tissue never goes into tissue
What are lymph nodes?
Extremely organized structure
www.notesolution.com

Loved by over 2.2 million students

Over 90% improved by at least one letter grade.

Leah — University of Toronto

OneClass has been such a huge help in my studies at UofT especially since I am a transfer student. OneClass is the study buddy I never had before and definitely gives me the extra push to get from a B to an A!

Leah — University of Toronto
Saarim — University of Michigan

Balancing social life With academics can be difficult, that is why I'm so glad that OneClass is out there where I can find the top notes for all of my classes. Now I can be the all-star student I want to be.

Saarim — University of Michigan
Jenna — University of Wisconsin

As a college student living on a college budget, I love how easy it is to earn gift cards just by submitting my notes.

Jenna — University of Wisconsin
Anne — University of California

OneClass has allowed me to catch up with my most difficult course! #lifesaver

Anne — University of California
Description
st LECTURE 7 March 1 , 2011 MIDTERM: 36 multiple choice questions; 2158 in the medical sciences building for the tutorial Location is the lecture room Todays material will not be on the midterm Anatomical context where immune responses take place in body Movies are not testable material, just to fill in knowledge How do lymphocytes move around the human body? Lymphocyte migration o Lymphocytes always moving throughout body o Need to patrol body for infection, tumour cell growth or antigen, anything dangerous or foreign to host Lymphatic system network of conduits carrying lymph o plumbing o Anything dangerous is put into lymph nodes, where they are interrogated o Efferent going in o Afferent where lymphocytes leave the nodes Lymph interstitial fluid in tissues found between cells of body o Enters lymphatic vessels to be sampled in the lymph nodes Systemic infection, for example, spleen is first point of contact with immune cells with pathogen o Spleen filter agent for blood o Lymph nodes filter agent for lymph Dont need all lymph nodes to control body o Many can be absent o If one is absent the next one can take over the responsibilities Migration of lymphocytes Chemokines T cell will move towards chemokines T-cell chemokines different from b cell chemokines o Important to orchestrate cellular interactions for an immune response Chemokines work in a gradient o Imagine a drop of colouring into water o Concentration brightest at the source of chemokines Lymphocytes would keep going around in blood forever o But most infection they deal with are in tissue beds o So must enter lymph nodes to check for pathogen o They do so by sticking to endothelial cells of blood vessels, sense a chemokine gradient, and then squeeze through endothelial cells to get into tissues Proteins mediating sticking to the cells adhesion molecules www.notesolution.com
More Less
Unlock Document


Only pages 1-2 are available for preview. Some parts have been intentionally blurred.

Unlock Document
You're Reading a Preview

Unlock to view full version

Unlock Document

Log In


OR

Don't have an account?

Join OneClass

Access over 10 million pages of study
documents for 1.3 million courses.

Sign up

Join to view


OR

By registering, I agree to the Terms and Privacy Policies
Already have an account?
Just a few more details

So we can recommend you notes for your school.

Reset Password

Please enter below the email address you registered with and we will send you a link to reset your password.

Add your courses

Get notes from the top students in your class.


Submit