IMM340H1 Lecture Notes - Lecture 2: Alpha Defensin, Paneth Cell, Pattern Recognition Receptor
Document Summary
The epithelial cells are very tightly sealed to the next one by things called tight junctions where proteins are between the cells that stick them together. In the lungs theres lots of mucous, and the epithelial cells are covered with mucous and the cilia move things out. Lysozymes can damage the cell walls of bacteria. The skin is very thick, the keratinocytes differentiate in many ways, and they form many different layers. Theres a lipid la(cid:455)er that"s prote(cid:272)ti(cid:374)g us fro(cid:373) pathoge(cid:374)s. part of this lipid la(cid:455)er also (cid:272)o(cid:374)tai(cid:374)s so(cid:373)e defensins and they are secreted from the cells called lamellar bodies. The mucous is produced by goblet cells which are specialized epithelial cells. The movement of the cilia brings whatever particles in the mucous outwards. In the gut, we have the highest nuber of microbiota, the gastrointestinal tract, we have bacteria from the mouth until the rectum, and they increase in number as we go down.
