IMM250H1 Lecture Notes - Lecture 3: Immunoglobulin G, Granulocyte, Eosin
Document Summary
Soluble mediators of innate immunity: these mediators are produced following pamp/prr interactions to call other cells into action, or in the case of complement, to directly kill and contain the microbes: cytokines, complement. Pro-inflammatory cytokines inflammation, includes il-1beta, il-6, tnf, these make you feel sick, like give you fever for example. Interferons anti-viral defense, includes type-1 ifns which induces an antiviral state. Anti-inflammatory cytokines repair and healing, includes il-10, il-4, tgfbeta. Stem cells are found in the bone marrow. Dendritic cells are the main antigen presenting cell types for na ve t cells, they prime adaptive immunity, they degrade pathogens and present pieces of pathogens on their surface, they are the link between innate and adaptive immunity. Mast cells release histamine, causes vasodilation, lots of mucus, itching, designed to eject parasites from body, but cause symptoms of allergy in response to harmless entities. Natural killer cells: recognize and kill abnormal cells, provide early response to viral infection.
