MGY277H1 Lecture Notes - Lecture 10: Complement Component 5A, Complement System, Bile Acid

• School: UTSG
• Department: Molecular Genetics and Microbiology
• Course: MGY277H1
• Professor: William Navarre

Document Summary

First-line defenses are always on : body borders, digestive and respiratory tract, physical barriers. Skin: difficult for microbes to breach (tightly packed), constantly renewed: mucous membranes: line digestive, respiratory, genitourinary, constantly bathed in secretions to wash microbes away. Peristalsis of intestines, mucocilary escalator move microbes: antimicrobial substances. Lysozyme degrades peptidoglycan in tears, saliva, mucus, blood in blood, tears, sweat and other secretions (stomach acid, bile salts) Lactoferrin further binds fe: haptoglobin bind free hemoglobin from lysed rbc, albumen and calprotectin bind free zinc, commensal microflora, competitive exclusion of pathogen: cover binding sites, consume nutrients. Inflammatory response: c5a attacts phagocytes to area, c3a and c5a increase blood vessel permeability. Lysis of foreign cells: macs (membrane attack complexes) assemble in cell membranes of gram membranes, form pores. Pattern recognition receptors detect pamps/mamps (pathogen/microbe associated) and. Damps (host cell damage indicators) and mount a response: tlr on membranes of cells detect pamp, nlr in cytoplasm detect pamp or damp, rlr detect viral rna.