MGY378H1 Lecture Notes - Growth Factor, Helper Virus, Lentivirus

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redtermite204

4 May 2013

School

UTSG

Department

Molecular Genetics and Microbiology

Course

MGY378H1

Professor

Alan Cochrane

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Document Summary

Meristic acid causes it to be inserted into lower side of plasma membrane . C-type virus forms c-type indentation when released from cell. Other retroviruses called b and d type viruses form capsid in cytoplasm icosahedral cores form in cytoplasm, travel to membrane, then bud off. C type do not see viral assembly on viral membrane. Need to mature before beomcing infectious: because polyprotein need to be cleaved down to be infectious. Activate protease prior to release step catastrophic to virus lose all enzymes: through gag part of molecule. If receptor for virus is present or not. If virus enters but must be in right environment, as determined by promoter. If cell type is wrong and has wrong transcription factors, cannot read promoter of virus. Some viruses inuce sarcomas, others leukemias, and other work in other places of body going after specific tissue of body: virus does not provide transcription factors, polymerase all belonging to host.

Related Questions

QUESTION 1: The rabies virus primarily affects the nervous system. The specificity that the rabies virus has for neuronal host cells is primarily dictated by __________________________.

A. the helical shape of its viral capsid

B. the type of nucleic acid used for its viral genome (single-stranded, antisense RNA)

C. the spikes that protrude from its viral envelope

D. the segmented nature of its viral genome

QUESTION 2: Which of the following genome types has been observed in viruses? To be marked correct, you'll need to select all true statements, as there may be more than one correct answer.

A. Single-stranded RNA

B. Single-stranded DNA

C. Double-stranded RNA

D. Protein-based

QUESTION 3: Choose the correct statement about viral evolution.

A. RNA and DNA viral genomes evolve at equal rates.

B. Cellular genomes mutate at a faster rate than viral genomes due to their large size and increased chance of replicative mistakes.

C. DNA viruses mutate faster than RNA viruses because thymine is more susceptible to mutation than uracil.

D. RNA viruses mutate faster than DNA viruses due to a lack of proofreading replicative enzymes.

QUESTION 4: Your elderly patient is affected by shingles. After careful observation, you note that the virus responsible for the infection has an icosahedral capsid, is enveloped, and has double-stranded linear DNA as its genetic material. Based on this information, in which of the following viral families would you group this viral pathogen?

QUESTION 5: Which of the following is a key difference between lytic and lysogenic bacteriophage replication cycles?

A. Lysogenic bacteriophages release via host cell lysis, whereas lytic bacteriophages bud off from the host cell membrane.

B. The lytic replication cycle ends with host cell lysis and release of newly formed bacteriophage particles, whereas lysogenic replication leads to prophage formation.

C. Lytic replication requires an uncoating step, whereas in lysogenic replication, the bacteriophage's nucleic acid is directly injected into the host cell.

D. Whereas lytic replication enables the infection of several hosts, lysogenic replication only allows for infection of a single host cell.

QUESTION 6: Which of the following is an unsuitable culture method for an animal virus?

A. Direct inoculation of virus onto blood agar

B. Live animal inoculation

C. Tissue culture method

D. Injection of virus into embryonated eggs

MGY378H1 Lecture Notes - Growth Factor, Helper Virus, Lentivirus

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