Biochemistry 2288A Lecture Notes - Lecture 10: Dihydrolipoamide Dehydrogenase, Citric Acid Cycle, Pyruvate Dehydrogenase Complex
17 Jun 2016
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Document Summary
Several organic molecules are converted to acetyl coa in the mitochondrial matrix: In aerobic metabolism, pyruvate produced from glycolysis, is decarboxylated by the pyruvate dehydrogenase complex (contains multiple copies of three enzymes: pyruvate dehydrogenase, dihydrolipoyl transacetylase, dihydrolipoyl dehydrogenase) in the mitochondrial matrix, to produce co2 (waste product), nadh, acetyl coa. Fat is a major source of energy for most non-photosynthetic organisms; fatty acids derived from fat are converted into acetyl coa in the mitochondrial matrix. In aerobic bacteria, glycolysis, acetyl coa production, and citric acid cycle take plan in the cytosol. Preserved in present-day cells: chloroplasts and mitochondria evolved from bacteria that were engulfed by ancestral cells more than a billion years ago, a mitochondrion undergoes a fission process conceptually similar to bacterial division. Atp to function normally and are sensitive to mitochondrial defects. In cardiac muscle cells, mitochondria are located close to the contractile apparatus, in which atp hydrolysis provides the energy for contraction.
