Biology 2382B Lecture Notes - Lecture 4: Oligosaccharyltransferase, Secretion, Signal Peptidase

27 views2 pages

Document Summary

Typical mammalian cell: 10,000 proteins, must be localized correctly. Newly made peptides must be directed to the correct destination. Targeting: direct proteins to the right destinations (organelles), during or after synthesis. Sorting: direct proteins to the secretory pathway (er, golgi, lysosomes: occurs after targeting, cells being sorted must first be targeted to the er. General principles of protein synthesis, targeting, and sorting. Other proteins are synthesized by ribosomes attached to er (the rough er): those which reside in er and proteins which are sorted to pm, golgi, lysosomes: secreted proteins must first go through the er. 2 major protein-sorting pathways are known: nonsecretory and secretory. Uninterrupted membranous tubules & vesicles separated from cytoplasm. Rer has ribosomes on the tubules (cisterna stacked) Microsome: created when we disrupt cells, er no longer assumes complex form, er reforms into vesicles called microsomes: still have some of the inner and outer associated proteins.

Get access

Grade+
$40 USD/m
Billed monthly
Grade+
Homework Help
Study Guides
Textbook Solutions
Class Notes
Textbook Notes
Booster Class
10 Verified Answers
Class+
$30 USD/m
Billed monthly
Class+
Homework Help
Study Guides
Textbook Solutions
Class Notes
Textbook Notes
Booster Class
7 Verified Answers

Related Documents

Related Questions