Microbiology and Immunology 3300B Lecture Notes - Lecture 30: Pertussis Toxin, Factor H, Lyme Disease
20 May 2016
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Document Summary
Coats surface with factor h, which is bound to the bacteria by exotoxin cspa: factor h inhibits complement disposition. Coats surface with host proteins: hides antigens and cell surface from antibodies, does this by binding non specific charged lipids in bacterial membrane. Protein a and g: binds to igg via fc domain, prevents opsonization, phagocytosis and complement activation. Bind to myd88 to prevent mydd88-tlr association. Pertussis toxin modifies g-protein alpha to prevent gdp->gtp. Means that immune cell is not able to migrate into the peripheral tissue and even if they are able to go to the periphery, they are not able to phagocytize. Hemolysins and leukolysins: pore forming toxins which lyse leukocytes and also use them to get out of the phagosome. Enter via tight junctions in the gut villus and then enter the lacteal. Food borne pathogen that aren"t affected by refrigeration.
