Pathology 3240A Lecture Notes - Lecture 9: Granulation Tissue, Cardiac Muscle, Cirrhosis
4 Dec 2016
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Inc in viscosity, fluid disappears => appearance of more cells (same number but less fluid so its more dense) Beginning of margination of wbc in the periphery(normally rbc) Cross cut of endothelial cells => create gaps, mediated by histamines (inc permeambility but only lasts a few min) Most important way to inc permeability: endothelial cells themselves being damaged. Cells become sticky and stick inside of the endothelium. Wbc are motile, attracted to receptors containting chemotactic factors => move towards site of injury. Facilitation occurs bcz chemotactic receptor in the site of injury. Regeneration and repair (the restoration of damaged tissue) Removal of celluar and tissue debris and replacement of cells and tissues lost. Regeneration = replaced by identical cells (physiologic/pathologic). Repair = identical or diff cells is pathological. Other cells that do not regenerate (lost in embryonic life), neurons and cardiac muscle cells (can put something else instead but cant be replaced with the same structure and functionality)
