Pathology 3240A Lecture Notes - Lecture 9: Acidophile, Anaphylatoxin, Basophil

• School: Western University
• Department: Pathology
• Course: Pathology 3240A
• Professor: Aaron Haig

Document Summary

Part 1: mediators of increased vascular permeability in inflammatory edema. Cell derived vasoactive mediators: arachidonic acid metabolites: they are derived from cell membrane phospholipids. 1: release of arachidonic acid by phospholipases (lysosomes) is induced by mechanical, chemical and physical stimuli, the end products are prostaglandins and leukotrienes, prostaglandins produce vasodilatation and increased permeability, leukotriens increase permeability and have chemotactic activity. In addition they produce broncho spasm (something asmatics suffer from. In order for the cell membrane to be broken down you need phospholipase: platelet activating factor (paf), generated by stimulation of practically all inflammatory cells, endothelial cells and damaged tissue cells. In addition to being a powerful vasodilator, it also increases the permeability: other functions include: stimulation of platelets, inflammatory cells and endothelial cells. It is best known for its ability to produce aggregation of platelets at the site of injury.