Pathology 3500 Lecture Notes - Lecture 2: Membrane Potential, Trachea, Muscle Hypertrophy

• School: Western University
• Department: Pathology
• Course: Pathology 3500
• Professor: shepherd

Document Summary

Lecture 2 - cell injury, adaption and cell death 1. Rudolf virchow is the father of cellular pathology: all cells arise from another cell, and all disease is cellular. Cells constantly adjusting to accommodate extracellular stresses: maintain homeostasis, cells are working all the time, they are metabolically active. Maintain a fairly narrow physiological range or there are problems. The normal cell: disease starts in the cell, three target areas where disease targets, nucleus, genetic material, rna synthesis, cytoplasm, protein synthesis, mitochondria (energy production, cell/plasma membrane. If the environmental changes exceed the capacity of the cell to maintain homeostasis get injury. Disease: the pattern of response of living organisms to injury, disease results when adaptive mechanisms fail (heart attack, cells could(cid:374)"t adapt) o(cid:396) the adapti(cid:448)e mechanism itself becomes harmful (big heart not functioning properly) Immune reactions: bod(cid:455) (cid:396)ea(cid:272)ti(cid:374)g (cid:449)he(cid:374) the(cid:455) should(cid:374)"t, ex.