Class Notes (838,382)
Canada (510,868)
Pharmacology (365)
Lecture 10

Lecture 10 - Appraise drug literature.pdf

1 Page
84 Views
Unlock Document

Department
Pharmacology
Course
Pharmacology 4350A/B
Professor
Rommel Tirona
Semester
Winter

Description
Clinical Endpoint RCTI Therapy Surrogate Endpoint RCT increased death canide improved PVCs post-MI improved lipids, endothelial function increased stroke, MI estrogen increased death improved lipids torcetrapib improved BP increased CHF, stroke doxazosin increased death vitamin E improved redox status clofibrate improved lipids increased death Clinical Endpoint RCTI Therapy Surrogate Endpoint RCT increased death canide improved PVCs post-MI improved lipids, endothelial function increased stroke, MI estrogen increased death improved lipids torcetrapib improved BP increased CHF, stroke doxazosin increased death vitamin E improved redox status clofibrate improved lipids increased death Lecture10 - Appraise drug literature April-22-12 5:08 PM Strongestdesign 1. SystemicreviewofwellconductedRCT 2. IndividualRCT 3. Systemicreviewofcohortstudies(observation) 4. Individualcohortstudy 5. Casecontrolstudy 6. Caseseries 7. Expertopinion RCT - Strongcomponents 1. Randomization 2. Concealedallocation 3. Blind 4. Minimallosstofollow-up 5. Intentiontotreat - EXAMPLE:Perindopril(treatcardiovascularevents)(ACEinhibitor) Classvsagents - Differencesin 1. Lipophilicityorhydrophilicity 2. T1/2 3. Dose-response 4. Toxicity 5. Metabolism 6. Druginteractions - Examplesofclasseffectsdifferentfromagent 1. Rosiglitazoneincreasevascularevents+pioglitazone maydecrease 2. Rosuvastatinno effectonheartfailure+atorvastatin helpsheartfailure ToxicityDetection - RCTSare poorat detecting ○ Onlyyounghealthyvolunteerswhilemostdrugtoxicityoccurtosenior/renal/hepaticfailure
More Less

Related notes for Pharmacology 4350A/B

Log In


OR

Join OneClass

Access over 10 million pages of study
documents for 1.3 million courses.

Sign up

Join to view


OR

By registering, I agree to the Terms and Privacy Policies
Already have an account?
Just a few more details

So we can recommend you notes for your school.

Reset Password

Please enter below the email address you registered with and we will send you a link to reset your password.

Add your courses

Get notes from the top students in your class.


Submit