Pharmacology 3620 Lecture Notes - Lecture 5: Suppository, Dermis

• School: Western University
• Department: Pharmacology
• Course: Pharmacology 3620
• Professor: Brad Urquhart

Document Summary

Oral: most common route, minimal absorption in stomach (small surface area, mucous), Absorbed drugs from the intestine are carried by portal circulation to liver (primary. Routes of drug administration: most absorption occurs in the small intestine (large surface area - million of villi). site of drug metabolism). patients emptying. environments. acid. of the enteric coating. Why some undergo large degree of rst pass metabolism. Food can delay absorption, and prevent stomach irritation - decreased gastric. Taken on empty stomach - undergo rapid gastric emptying. Enteric coating: coating on some drugs which prevent disintegration in acidic. Coating dissolves as it moves into the alkaline duodenum. Done to prevent irritating drugs or the drugs being broken down by stomach. Drugs that change ph of stomach (antacids) can cause premature disintegration. Rectal: drug inserted into rectum as a suppository which dissolves and is absorbed into.