Pharmacology 3620 Lecture Notes - Lecture 4: Diabetes Mellitus Type 1, Diabetes Canada, Metformin

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Notes from previous lecture on type 1 dm: glut4 transporter is in the heart and its main energy source is amino acids. Obesity is key in type 2, geneics plays a role. Obesity can lead to adult onset type 2 dm. Weight loss alone will oten improve type 2 diabetes in its early stages. Maximal insulin secreion in response to glucose reaches its maximum tolerance then begins to become exhausted and begins to drop within the 1st 5 years. Lipid deposiion can end up in all issues and create signaling and insulin resistance in muscle, liver, etc. Emphasis on weight loss (exercise, diet, makes a big diference) Body generates more insulin in response to increase in insulin resistance which is the beginning of type 2 dm. Beta cells exhaust and can"t keep up with the demand of insulin then hormone levels drop. Insulin secreion and glucose clearance are impaired during dm.

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