BIOL 2021 Lecture Notes - Nuclear Localization Sequence, Nuclear Export Signal, Nuclear Pore

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16 Oct 2011
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Only have plasma membrane; so one compartment only. Cytoplasm includes organelles (mitochondrion) found in cytosol. Ribosome: found in cytosol and attached to er. Functions of organelles: increase surface area of membranes, divide cytoplasm into specialized compartments. Figure 1 the major intracellular compartments of an animal cell. Er, golgi, endosomes, lysosomes: mitochondria, plastids (in plants only) Mito and plastids have own dna and do some protein synthesis and protein import. Topology: study of mathematics of holes and maps. If things have to make a hole to get out of cell then things are topologically different. Lumen of the er= outside of cell (same space) So must be connected by vesicle traffic. All organelles come from pre existing organelles. No signal= proteins stay in cytosol on free ribosomes. With signal= proteins are directed to the right organelle. Proteins are imported with a sorting receptor (on organelles); the sorting signal recognized by receptor sorting receptor.

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