Chapter 9 â Microbial Genetics
A. The sum total of genetic material of the cell is called the ________, and in bacteria consists
of the ____________ and __________.
B. A chromosome contains hundreds of _______ that are composed of ds _____.
C. What are the 3 components of a nucleotide?
D. Name the 4 nucleotides. (No abbreviations)
E. What type of bonds hold the two strands of DNA together?
Chapter 9 â Microbial Genetics
A. The sum total of genetic material of the cell is called the ________, and in bacteria consists
of the ____________ and __________.
B. A chromosome contains hundreds of _______ that are composed of ds _____.
C. What are the 3 components of a nucleotide?
D. Name the 4 nucleotides. (No abbreviations)
E. What type of bonds hold the two strands of DNA together?
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Chapter 10
1.Outline the history of our knowledge on DNA up to Watson and Crick. What were the main contributions made by each researcherâs key experiment?
2.Explain the setup of the Hershey and Chase experiment, what would the results have been if protein was the genetic material?
3.Draw the structure of a DNA nucleotide, labeling each main component correctly. How does an RNA nucleotide differ?
4.If a section of double stranded DNA contains 19% Adenine, how much Thymine is present?
5.You are a researcher studying the genetic basis of heart attacks and have been working to determine the expression levels of different genes that might contribute to cancer formation. You obtain the DNA methylation status of five genes of interest (the data are shown in the table below). The plus (+) sign indicates the level of DNA methylation; more plus signs correlates with increased methylation levels.Based on this information which genes would you predict to have the highest rate of transcription?
Gene | Methylation levels |
1 | ++ |
2 | +++++ |
3 | +++ |
4 | ++ |
5 | + |
What are the characteristics of the 3 main DNA forms?
Chapter 11
What are the different types of chromatin?
What are the structures and important roles for telomeres and centromeres?
What are the differences found between eukaryotic chromosomes and mitochondrial?
Chapter 12
Explain each of the different models of replication.
If you grow a culture of bacteria in media with radioactive nucleotides so that all DNA in the cells include radioactive nucleotides and then place the bacteria in new non radioactive media. After two rounds of replication what proportion of the DNA molecules will contain radioactivity?
Summarize the similarities and differences between rolling-circle replication, theta replication and linear eukaryotic replication.
What are the functions of the different DNA polymerases found in eukaryotic cells?
Draw a replication fork and include all key components and orientations. (Leading/lagging strands, DNA helicase, RNA primer and DNA gyrase)
What is the Holliday model of recombination and what are the necessary steps?
Chapter 13
What are the different types of RNA and what roles do they play?
Describe the properties and functions of each of the RNA polymerases and how they differ depending on the organism.
Describe in detail the process and mechanisms of transcription in both prokaryotes and eukaryotes.
Chapter 14
What are the primary purposes of each of the three post transcriptional modifications that occur in eukaryotic cells.
What is alternative splicing and what role does it play in the cell?
How is ribosomal RNA processed after transcription?
How do siRNA and miRNA work, describe/draw out the process in detail.
1. Characters that show a continuous range of variation, such as height and eye color, usually are controlled:
a. | by a single gene with two alleles that are codominant. |
b. | by many genes with an additive effect. |
c. | by epistatic interactions between two genes. |
d. | mainly by the environment, with only a small genetic component. |
2. In humans, red-green colorblindness is inherited as a sex-linked recessive trait. In order for a woman to be red-green colorblind, which of the following statements must be true.
a. | Her mother must be red-green colorblind. |
b. | All of her brothers must be red-green colorblind. |
c. | Her father must be red-green colorblind. |
d. | All of the above statements must be true if a woman is red-green colorblind. |
3. The x-ray crystallography data collected by Rosalind Franklin suggested to Watson and Crick that the:
a. | structure of DNA is a double helix. |
b. | two strands of the DNA molecule are joined by hydrogen bonds between the bases. |
c. | four bases within DNA pair in a specific way. |
d. | two strands of the DNA molecule are joined by covalent bonds between the bases. |
4. In the genetic code, _________ one amino acid.
a. | one nucleotide specifies |
b. | two nucleotides specify |
c. | three nucleotides specify |
d. | four nucleotides specify |
5. During Meiosis I, a homologous pair of chromosomes may not separate, resulting in daughter cells that have extra chromosomes or are missing chromosomes. This can lead to genetic disorders, including Down Syndrome. This phenomenon is called:
a. | independent assortment. |
b. | nondisjunction. |
c. | segregation. |
d. | crossing over. |
6. You are a human geneticist studying the incidence of retinitis pigmentosa in the residents of Tristan de Cunha, a group of small islands in the middle of the southern Atlantic Ocean. The allele for retinitis pigmentosa, which causes a form of blindness, is inherited as an autosomal recessive. You have determined that the frequency of this allele (r) in the population is 0.4 (40%). Using the principles of the Hardy-Weinberg rule, you would estimate the frequency of individuals who are heterozygous for this allele (Rr) in the population to be:
a. | 0.16 (16%) |
b. | 0.24 (24%) |
c. | 0.36 (36%) |
d. | 0.48 (48%) |
7. Natural selection acts at the level of the:
a. | phenotype. |
b. | gene. |
c. | population. |
d. | nucleotide. |
8. You are working with pea plants, trying to recreate the experiments that Mendel performed. You are doing a dihybrid cross with a plant that is heterozygous for both seed shape and seed color, with the genotype RrYy. Which allelic combinations would you expect to find in the gametes produced by this plant?
a. | This plant would produce only RY and ry gametes. |
b. | This plant would produce only RrYy gametes. |
c. | This plant would produce RY, Ry, rY, and ry gametes. |
d. | You cannot determine which gametes this plant can produce without knowing the genotypes of its parents. |
9. Biochemist Erwin Chargaff found that in DNA there is a special relationship between the four bases that we now call Chargaff's rule. His observation was that, in an organism's genome the:
a. | percentage of A nucleotides = the percentage of T nucleotides, and the percentage of C nucleotides = the percentage of G nucleotides. |
b. | four bases all occur in an equal frequency (25%) within each organism. |
c. | percentage of A nucleotides = the percentage of G nucleotides, and the percentage of C nucleotides = the percentage of T nucleotides. |
d. | genetic material is composed of proteins, not DNA. |
10. During DNA replication:
a. | each strand of the double helix acts as a template for the synthesis of a new strand. |
b. | the enzyme DNA polymerase adds nucleotides to the strand being synthesized. |
c. | the bases A,C,G and T are required. |
d. | All of the above are true of DNA replication. |
11. During translation, amino acids are joined by peptide bonds to make polypeptides. The formation of these peptide bonds is catalyzed by:
a. | DNA. |
b. | mRNA. |
c. | tRNA. |
d. | rRNA. |
12. If an allele (R) at a gene with two alleles shows complete dominance, individuals with the genotypes ______ will have the same phenotype.
a. | RR and rr. |
b. | RR and Rr |
c. | Rr and rr |
d. | Each of the three possible genotypes will have a different phenotype. |
What step in DNA replication precedes the pairing of complementary bases?
A. | polymerization of DNA. | |
B. | formation of the histone core. | |
C. | mitotic division. | |
D. | separation of the two strands. | |
E. | joining of the two strands. |
In eukaryotes, transcription occurs in the
A. | ribosome. | |
B. | mitochondria. | |
C. | cell membrane. | |
D. | cytoplasm. | |
E. | nucleus. |
Normal human body cells contain how many chromosomes?
A. | 46 | |
B. | 22 | |
C. | 23 | |
D. | 44 | |
E. | 42 |
Hershey and Chase performed an experiment in which they used radioactive isotopes to phosphorus and sulfur to label different components of bacterial viruses. Their results clearly showed that
A. | the viruses did not contain protein. | |
B. | genetic material normally contains radioactive isotopes. | |
C. | the viruses did not contain DNA. | |
D. | protein was entering into the infected bacteria. | |
E. | DNA was entering into the infected bacteria. |
A package of histones with DNA wrapped around them forms spherical structures called
A. | nucleosomes. | |
B. | lysosomes. | |
C. | ribosomes. | |
D. | nucleoli. | |
E. | chromatin. |
DNA replication
A. | does not require proteins. | |
B. | is constantly happening in a cell. | |
C. | occurs in G1 of interphase. | |
D. | takes place in the nucleus of the cell. | |
E. | occurs in the cytoplasm of the cell. |
The two subunits of the ribosome join during
A. | promotion of transcription. | |
B. | initiation of translation. | |
C. | termination of transcription. | |
D. | termination of translation. | |
E. | elongation. |
DNA replication of a single DNA molecule is referred to as semiconservative because
A. | each of the two DNA molecules will consist of one parental strand and one newly synthesized strand. | |
B. | all the DNA strands in the two DNA molecules will have both parental and newly synthesized DNA. | |
C. | it results in two nonidentical DNA molecules. | |
D. | of the two DNA molecules, one is made up totally of parental DNA, while the other is entirely newly synthesized DNA. | |
E. | one DNA strand is replicated continuously, while the other must be replicated discontinuously. |
The bases are bonded to what part of the backbone of the DNA molecule?
A. | the 4â carbon atom of the sugar molecule. | |
B. | the 3â carbon atom of the sugar molecule. | |
C. | the 5â carbon atom of the sugar molecule. | |
D. | the 1â carbon atom of the sugar molecule. | |
E. | the 2â carbon atom of the sugar molecule. |