IMM250H1 Study Guide - Midterm Guide: Cytotoxic T Cell, Complement Deficiency, Nonsteroidal Anti-Inflammatory Drug
Document Summary
Innate immunity: cellular and humoral mediators of defense. Pathogen breaches barrier and then : releases mamps, detected by tlr/nod proteins (nlr) Activates signal transduction (interaction between mamp and prm activates signal transduction: activates (tf) nf b, irf (which) controls cytokine production, releases damps, detected by nlrp (in the nlr family) Activates signal transduction: activates inflammasome, controls il-1 production. Summary of tlrs and nlrs: tlrs, nlrs, nod proteins, detect mamps - through adaptor myd88 for nfkb and trif for irf. Signal transduction to nf b and irf: leads to cytokine and interferon production. Detect mamps (peptidoglycan) - using adaptor rip2: signal transduction to nf b, leads to cytokine production. Detect damps (ros) - through adaptor asc: signal transduction to inflammasome activation production of il-1 (a cytokine - we will talk about this today) Innate immune mediators: both cellular and humoral (ie secreted: cells of the innate system, secreted mediators of the innate system.
