PHAR 100 Lecture Notes - Chemotherapy, Microorganism, Arsanilic Acid

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Potency and efficacy potency refers to the amount of drug that must be given to obtain a particular response efficacy refers to the maximal response that can be obtained with the drug more important. Dose response as dose increases so does the response: variability in the response between individuals, variability between drugs. therapeutic dose must be less than the toxic dose, ex: chemotherapy toxicity at therapeutic doses. Adding up frequency dist = log dose curve. Therapeutic index td50/ed50 the higher the number the lower the probability that the drug will cause an adverse effect. chose 50% where curve is change quickly and linearly therapeutic window: ~90% response with little adverse effects. Chemotherapy early theories of disease suggested that the body was overcome by evil spirits and that treatment was designed to drive off evil spirits, burning of sulphur, blood letting.

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