BCHM 2021 Chapter Notes - Chapter 14: Paclitaxel, Cell Migration, Centrosome
21 Oct 2012
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Document Summary
Cytoskeleton strength and shape and movement of cells. The regulation of these = helps build the cytoskeleton. They form flexible filaments form a network bundles. These are generally found in the cortex just beneath the plasma membrane. General principles of dynamics dynamic, constantly in flux assembled from small subunits. The protofilaments have alpha and beta alternating microtubules = 13 protofilaments. Alpha = minus end and beta = plus end. Protofilaments actin subunits = head to tail. Nucleotide hydrolysis atp or gtp hydrolyze after binding. The t form goes to the d form this means that there is a lower affinity. High monomer concentration t form to plus and low concentration. Rapid shrinking for plus end intermediate concentration. Dynamic: requires a supply of energy atp/gtp hydrolysis exchange the adp or gdp for a fresh. They join at junction and are stuck together.
