BIOL 2020 Chapter Notes - Chapter 8: Pyrrole, Porphyrin, Protoporphyrin Ix

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Biol2020 : chapter 8 hemoglobin, an allosteric protein. Hemoglobin component of red blood cells; carries oxygen from lungs to tissues and contributes to transport of carbon dioxide and hydrogen ions back to lungs. Myoglobin located in muscles; facilitates diffusion of oxygen to cellular sites that require oxygen and provides a reserve supply of oxygen in times of need. 8. 1 hemoglobin displays cooperative behaviour cooperative effect in hemoglobin oxygen must be transported in blood from lungs where partial pressure of oxygen is high (100torr) to tissues where partial pressure of oxygen is low (20torr) Allosteric regulators released at tissues can further enhance oxygen release. 8. 2 myoglobin and hemoglobin bind oxygen in heme groups. Myoglobin single polypeptide chain; contains mostly -helices that are linked to one another by turns to form globular structure; recurring structure called globin fold and also seen in hemoglobin. Myoglobin can exist in two forms: deoxymyoglobin : oxygen free form, oxymyoglobin : form having bound oxygen molecule.

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