Prior Knowledge Questions (Do these BEFORE using the Gizmo.)

1. Suppose you want to design and build a house. How would you communicate your design plans with the construction crew that would work on the house? 

 

 

2. Cells build large, complicated molecules such as proteins. What do you think cells use as their “design plans” for proteins?

 

Which of the following factors does NOT contribute to our inability to predict protein tertiary structure using only our knowledge of protein primary structure?

Question: You have been asked to design a drug to inhibit BCR-ABL in an effort to treat CML. Using your knowledge of enzyme catalyzed reactions and the BCR-ABL kinase, propose a drug development strategy to combat CML.

*regular Abl protein is regulated by other molecules

*BRC-ABL has mutant kinase that leads to cancer

What are the three functions of the DNA molecule?