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Department
Biochemistry
Course
BCH311H1
Professor
Kelley
Semester
Winter

Description
BCH311Jan 20part 2Manipulation and molecular characterization of nucleic acids DNA molecular streucturegenomic structuregenomic sequence governs function Restriction nucleasesfirst tool to allow nucleic acids to be systematically manipulated Before problem of random breakagesget different pieces different sizes etcSame sequence backwards and forwards DNA molecules are asymmetric duplexes Restriction nuclease Blue and green helices and sheets biding to DNA Into major grooveMakes two cutsbut same place in the two sequences Cuts are denoted by arrows Sticky endsstrands without complementPrecise identical cut time after time Gel electrophoresis Nucleic acids flow through gel because of electric current Pattern of gel indicate size of fragment Restriction nucleases provide tool for DNA manipulat
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